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KMID : 1147220180190040140
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Journal of Biomedical and Translational Research
2018 Volume.19 No. 4 p.140 ~ p.145
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Successful remission with L-CHOP for primary mediastinal B-cell lymphoma in a young Maltese dog
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Chang Sei-Young
Kim Hak-Hyun
Kang Ji-Houn
Kang Byeong-Teck
Chang Dong-Woo
Na Ki-Jeong
Yang Mhan-Pyo
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Abstract
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A one-year-old, intact female, Maltese dog was presented with a history of anorexia and regurgitation. Thoracic radiographs and ultrasonography scans suggested an abnormal mass in the cranial mediastinal region, and computed tomography confirmed the origin of this mass. Ultrasound-guided fine needle aspiration cytology showed the presence of intermediate to large lymphoid cells showing mitotic figures. B-cell lymphoma was confirmed by the result of a polymerase chain reaction assay for antigen receptor rearrangement, therefore the patient was diagnosed with primary mediastinal large B-cell lymphoma (PMBL). The patient underwent L-CHOP (L-asparaginase, cyclophosphamide, doxorubicin, vincristine, prednisolone)-based chemotherapy, and showed complete tumoral remission from the beginning of chemotherapy. Seventy-two weeks after the completion of chemotherapy, the patient is still alive without any evidence of metastasis or relapse. A standardized treatment protocol has yet to be established for primary mediastinal lymphoma in dogs. This case report describes the complete remission of PMBL by an L-CHOP-based chemotherapy protocol in a young Maltese. Clinicians should consider that L-CHOP based chemotherapy may be useful against PMBL in dogs.
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KEYWORD
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canine, lymphoma, chemotherapy, mediastinal mass, regurgitation
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